Pulsating tandem microbubble for localized and directional single-cell membrane poration.

نویسندگان

  • G N Sankin
  • F Yuan
  • P Zhong
چکیده

The interaction of laser-generated tandem microbubble (maximum diameter of about 50  μm) with single (rat mammary carcinoma) cells is investigated in a 25-μm liquid layer. Antiphase and coupled oscillation of the tandem microbubble leads to the formation of alternating, directional microjets (with max microstreaming velocity of 10  m/s) and vortices (max vorticity of 350 000  s{-1}) in opposite directions. Localized and directional membrane poration (200 nm to 2  μm in pore size) can be produced by the tandem microbubble in an orientation and proximity-dependent manner, which is absent from a single oscillating microbubble of comparable size and at the same stand-off distance.

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عنوان ژورنال:
  • Physical review letters

دوره 105 7  شماره 

صفحات  -

تاریخ انتشار 2010